Discovery of N-(1-(6-Oxo-1,6-dihydropyrimidine)-pyrazole) Acetamide Derivatives as Novel Noncovalent DprE1 Inhibitors against Mycobacterium tuberculosis

Author:

Yang Liu1,Hu Xueping2,Lu Yang1,Xu Ruolan1,Xu Yaping1,Ma WanLi34,Alam Md Shah3456,Zhang Tianyu3456ORCID,Chai Xin1,Lei Yixuan1,Ye Qing1,Dong Xiaowu1ORCID,Kang Yu1ORCID,Che Jinxin1,Hou Tingjun1ORCID,Li Dan17ORCID

Affiliation:

1. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China

2. Institute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Qingdao 266237, China

3. State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China

4. University of Chinese Academy of Sciences, Beijing 100049, China

5. China-New Zealand Joint Laboratory of Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), Guangzhou 510530, China

6. Guangdong-Hong Kong-Macau Joint Laboratory of Respiratory Infectious Diseases, Guangzhou 510530, China

7. Jinhua Institute of Zhejiang University, Jinhua ,Zhejiang321000, China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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