Discovery of <b>CVN417</b>, a Novel Brain-Penetrant α6-Containing Nicotinic Receptor Antagonist for the Modulation of Motor Dysfunction-Reference-Cited by-同舟云学术

Discovery of CVN417, a Novel Brain-Penetrant α6-Containing Nicotinic Receptor Antagonist for the Modulation of Motor Dysfunction

Published:2023-08-31 Issue:17 Volume:66 Page:11718-11731
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Christie Louisa A.¹²,Brice Nicola L.¹²,Rowland Anna¹²,Dickson Louise¹²^ORCID,Anand Rishi³,Teall Martin¹²,Doyle Kevin J.¹^ORCID,Narayana Lakshminarayana⁴,Mitchell Christine²,Harvey Jenna R. M.¹²,Mulligan Victoria¹²,Dawson Lee A.¹,Cragg Stephanie J.³^ORCID,Carlton Mark¹²,Bürli Roland W.¹^ORCID

Affiliation:

1. Cerevance Limited, 418 Cambridge Science Park, Cambridge CB4 0PZ, United Kingdom

2. Takeda Cambridge Limited, 418 Cambridge Science Park, Cambridge CB4 0PZ, United Kingdom

3. Centre for Cellular and Molecular Neurobiology, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom

4. Aragen Lifesciences Limited, Plot #284A (part), Bommasandra-Jigani Link Road Industrial Area, Bengaluru 562106, India

Funder

Takeda Cambridge Ltd

Cerevance Ltd

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00630

Reference33 articles.

1. X-ray structure of the human α4β2 nicotinic receptor

2. Nicotinic Acetylcholine Receptor α7 Subunit Is an Essential Regulator of Seizure Susceptibility

3. Nicotinic acetylcholine receptors: Therapeutic targets for novel ligands to treat pain and inflammation

4. nAChR dysfunction as a common substrate for schizophrenia and comorbid nicotine addiction: Current trends and perspectives

5. Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an α7-nAChR, α9-nAChR Antagonist and of a Pro-Oxidant Mitocan

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