Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen

Author:

Shell Devan J.1ORCID,Foley Caroline A.1ORCID,Wang Qinhong2,Smith Chelsea M.3,Guduru Shiva K. R.1,Zeng Hong4,Dong Aiping4,Norris-Drouin Jacqueline L.1,Axtman Matthew1,Hardy P. Brian1,Gupta Gaorav23,Halabelian Levon45ORCID,Frye Stephen V.12ORCID,James Lindsey I.12ORCID,Pearce Kenneth H.12ORCID

Affiliation:

1. UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

2. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

3. Lineberger Comprehensive Cancer Center, Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

4. Structural Genomics Consortium, University of Toronto, Ontario M5S 1A1, Canada

5. Department of Pharmacology and Toxicology, University of Toronto, Ontario M5S 1A1, Canada

Funder

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill

Bayer

Merck KGaA

Genentech

Pfizer

Innovative Medicines Initiative

Bristol-Myers Squibb

Genome Canada

Boehringer Ingelheim

Janssen Pharmaceuticals

Eshelman Institute for Innovation, University of North Carolina at Chapel Hill

Takeda Foundation

Structural Genomics Consortium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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