Discovery of Potent Agonists for the Predominant Variant of the Orphan MAS-Related G Protein-Coupled Receptor X4 (MRGPRX4)
Author:
Affiliation:
1. Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany
2. PharmaCenter Bonn, University of Bonn, Brühler Straße 7, D-53121 Bonn, Germany
Funder
Bundesministerium f?r Bildung und Forschung
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01013
Reference39 articles.
1. A Diverse Family of GPCRs Expressed in Specific Subsets of Nociceptive Sensory Neurons
2. Proenkephalin A gene products activate a new family of sensory neuron–specific GPCRs
3. Characterization of the Mas-related gene family: structural and functional conservation of human and rhesus MrgX receptors
4. MAS-related G protein-coupled receptors X (MRGPRX): Orphan GPCRs with potential as targets for future drugs
5. MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus
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