Discovery and SAR of JTE-151: A Novel RORγ Inhibitor for Clinical Development-Reference-Cited by-同舟云学术

Discovery and SAR of JTE-151: A Novel RORγ Inhibitor for Clinical Development

Published:2024-01-03 Issue:2 Volume:67 Page:952-970
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Maeba Takaki¹²,Hirata Kazuyuki¹,Kotoku Masayuki³^ORCID,Seki Noriyoshi¹,Maeda Katsuya¹,Hirashima Shintaro¹,Yamanaka Hiroshi¹,Sakai Takayuki¹,Obika Shingo¹,Hori Akimi¹,Hara Yoshinori¹,Noji Satoru¹^ORCID,Suwa Yoshihiro¹,Yokota Masahiro¹,Fujioka Shingo¹,Yamaguchi Takayuki⁴,Katsuda Yoshiaki¹,Hata Takahiro¹,Miyagawa Naoki¹,Arita Kojo⁴,Nomura Yukihiro¹,Taniguchi Toshio¹,Asahina Kota¹,Aratsu Yusuke¹,Naka Yuichi¹,Adachi Tsuyoshi¹,Nomura Akihiro¹,Akai Shota¹,Oshida Shin-ichi⁵,Pai Sudhakar⁶,Crowe Paul⁷,Bradley Erin⁷,Steensma Ruo⁷,Tao Haiyan⁷,Fenn Morgan⁷,Babine Robert⁷,Li Xiaolin⁷,Thacher Scott⁷,Soeta Takahiro²^ORCID,Ukaji Yutaka²^ORCID,Shiozaki Makoto¹^ORCID

Affiliation:

1. Central Pharmaceutical Research Institute, Takatsuki Research Center, Japan Tobacco Inc., 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan

2. Division of Material Chemistry, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa, Ishikawa 920-1192, Japan

3. Akros Pharma Inc., Boston Office, One Broadway, 14th Floor, Cambridge, Massachusetts 02142, United States

4. Pharmaceutical Division, Japan Tobacco Inc., 3-4-1, Nihonbashi-Honcho, Chuo-ku, Tokyo 103-0023, Japan

5. Central Pharmaceutical Research Institute, Yokohama Research Center, Japan Tobacco Inc., 1-13-2, Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan

6. Akros Pharma Inc., 302 Carnegie Center, Suite 300, Princeton, New Jersey 08540, United States

7. Orphagen Pharmaceuticals, 11558 Sorrento Valley Road, Suite 4, San Diego, California 92121, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01933

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