Synthesis and Bioevaluation of 3-(Arylmethylene)indole Derivatives: Discovery of a Novel ALK Modulator with Antiglioblastoma Activities

Author:

Feng Lili1,Chen Xiang1,Sheng Gang1,Li Yingchun1,Li Yingying1,Zhang Yixuan2,Yao Kun3,Wu Zhouyue1,Zhang Rong1,Kiboku Takayuki4,Kawasaki Atsushi4,Horimoto Katsuhisa45,Tang Yamin1,Sun Meiling6,Han Feng127ORCID,Chen Dongyin1ORCID

Affiliation:

1. Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, China, International Joint Laboratory for Drug Target of Critical Illnesses, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China

2. Gusu School, Nanjing Medical University, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215001, China

3. Laboratory of Medicinal Chemical Biology, Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Soochow University, Suzhou 215006, China

4. Socium Inc., Tokyo 1350064, Japan

5. Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo 1350064, Japan

6. Department of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, China

7. Institute of Brain Science, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China

Funder

National Key Research and Development Program of China

Government of Jiangsu Province

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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