Development of N-Terminally Modified Variants of the CXCR4-Antagonistic Peptide EPI-X4 for Enhanced Plasma Stability-Reference-Cited by-同舟云学术

Development of N-Terminally Modified Variants of the CXCR4-Antagonistic Peptide EPI-X4 for Enhanced Plasma Stability

Published:2023-11-08 Issue:22 Volume:66 Page:15189-15204
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Harms Mirja¹^ORCID,Fabech Hansson Rikke²^ORCID,Gilg Andrea¹,Almeida-Hernández Yasser³^ORCID,Löffler Jessica⁴,Rodríguez-Alfonso Armando⁵⁶^ORCID,Habib Monica M. W.⁷⁸,Albers Dan¹,Ahmed Nermin S.⁷^ORCID,Abadi Ashraf H.⁷^ORCID,Winter Gordon⁴,Rasche Volker⁹,Beer Ambros J.⁴,Weidinger Gilbert¹⁰,Preising Nico⁵,Ständker Ludger⁵^ORCID,Wiese Sebastian⁶,Sanchez-Garcia Elsa³^ORCID,Zelikin Alexander N.²^ORCID,Münch Jan¹⁵^ORCID

Affiliation:

1. Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081, Germany

2. Department of Chemistry and iNANO Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus 8000, Denmark

3. Department of Biochemical and Chemical Engineering, Computational Bioengineering, Emil-Figge Str. 66, Dortmund 44227, Germany

4. Department of Nuclear Medicine, Ulm University Medical Center, Ulm 89081, Germany

5. Core Facility Functional Peptidomics, Ulm University Medical Center, Ulm 89081, Germany

6. Core Unit Mass Spectrometry and Proteomics, Ulm University Medical Center, Ulm 89081, Germany

7. Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt

8. Pharmaceutical Chemistry Department, School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, Cairo 11865, Egypt

9. Experimental Cardiovascular Imaging (ExCaVI), Ulm University Medical Center, Ulm 89081, Germany

10. Institute of Biochemistry and Molecular Biology, Ulm University, Ulm 89081, Germany

Funder

Deutsche Forschungsgemeinschaft

Medizinische Fakult?t, Universit?t Ulm

Baden-W?rttemberg Stiftung

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01128

Reference49 articles.

1. Discovery and Characterization of an Endogenous CXCR4 Antagonist

2. EPI-X4, a novel endogenous antagonist of CXCR4

3. Proteolytic processing of human serum albumin generates EPI-X4, an endogenous antagonist of CXCR4

4. Cathepsins: Proteases that are vital for survival but can also be fatal

5. Computational modeling and experimental validation of the EPI-X4/CXCR4 complex allows rational design of small peptide antagonists