Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide-Reference-Cited by-同舟云学术

Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide

Published:2024-01-04 Issue:2 Volume:67 Page:1197-1208
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Philippe Grégoire Jean-Baptiste¹²^ORCID,Huang Yen-Hua¹^ORCID,Mittermeier Anna³,Brown Christopher J.⁴,Kaas Quentin¹,Ramlan Siti Radhiah⁴,Wang Conan K.¹^ORCID,Lane David⁴,Loewer Alexander³,Troeira Henriques Sónia²^ORCID,Craik David J.¹^ORCID

Affiliation:

1. Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia

2. School of Biomedical Sciences, Queensland University of Technology, Translational Research Institute, Brisbane, Queensland 4102, Australia

3. Department of Biology, Technical University Darmstadt, 64287 Darmstadt, Germany

4. Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore

Funder

National Health and Medical Research Council

Australian Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01682

Reference58 articles.

1. Converting peptides into drugs targeting intracellular protein–protein interactions

2. Targeting transcription factors in cancer — from undruggable to reality

3. Awakening guardian angels: drugging the p53 pathway

4. MDM2, MDMX and p53 in oncogenesis and cancer therapy

5. Efficient p53 Activation and Apoptosis by Simultaneous Disruption of Binding to MDM2 and MDMX