A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy-Reference-Cited by-同舟云学术

A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy

Published:2023-08-31 Issue:17 Volume:66 Page:12185-12202
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kim Ho Young¹^ORCID,Chia Wai Kit¹,Hsieh Chia-Ju¹^ORCID,Saturnino Guarino Dinahlee¹,Graham Thomas J. A.¹^ORCID,Lengyel-Zhand Zsofia¹,Schneider Mark¹,Tomita Cosette¹,Lougee Marshall G.²,Kim Hee Jong³,Pagar Vinayak V.²,Lee Hsiaoju¹,Hou Catherine¹^ORCID,Garcia Benjamin A.³^ORCID,Petersson E. James²,O’Shea Jennifer⁴,Kotzbauer Paul T.⁴,Mathis Chester A.⁵,Lee Virginia M.-Y.⁶,Luk Kelvin C.⁶,Mach Robert H.¹^ORCID

Affiliation:

1. Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States

2. Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States

3. Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6303, United States

4. Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri 63110-1010, United States

5. Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States

6. Center for Neurodegenerative Disease Research, Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-2676, United States

Funder

U.S. Department of Health and Human Services

National Institute on Aging

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00779

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4. -Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies

5. Immunoelectron-microscopic demonstration of NACP/α-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies

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