Miconazole-like Scaffold is a Promising Lead for <i>Naegleria fowleri</i>-Specific CYP51 Inhibitors-Reference-Cited by-同舟云学术

Miconazole-like Scaffold is a Promising Lead for Naegleria fowleri-Specific CYP51 Inhibitors

Published:2023-12-12 Issue:24 Volume:66 Page:17059-17073
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sharma Vandna¹^ORCID,Madia Valentina Noemi²^ORCID,Tudino Valeria³^ORCID,Nguyen Jennifer V.¹^ORCID,Debnath Anjan¹^ORCID,Messore Antonella²^ORCID,Ialongo Davide²^ORCID,Patacchini Elisa²^ORCID,Palenca Irene⁴^ORCID,Basili Franzin Silvia⁴^ORCID,Seguella Luisa⁴,Esposito Giuseppe⁴^ORCID,Petrucci Rita⁵^ORCID,Di Matteo Paola⁵^ORCID,Bortolami Martina⁵^ORCID,Saccoliti Francesco⁶,Di Santo Roberto²^ORCID,Scipione Luigi²^ORCID,Costi Roberta²^ORCID,Podust Larissa M.¹^ORCID

Affiliation:

1. Skaggs School of Pharmacy and Pharmaceutical Sciences, Center for Discovery and Innovation in Parasitic Diseases, University of California San Diego, La Jolla, California 92093, United States

2. Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti, “Sapienza” Università di Roma, p.le Aldo Moro 5, Rome I-00185, Italy

3. Dipartimento di Biotecnologie, Università degli Studi di Siena, Chimica e Farmacia via Aldo Moro 2, Siena 53100, Italy

4. Department of Physiology and Pharmacology “V. Erspamer”, “Sapienza″ Università di Roma, p.le Aldo Moro 5, Rome I-00185, Italy

5. Dipartimento di Scienze di Base e Applicate per l’Ingegneria, “Sapienza” Università di Roma, Via Castro Laurenziano 7, Rome 00161, Italy

6. D3 PharmaChemistry, Italian Institute of Technology, Via Morego 30, Genova 16163, Italy

Funder

University of California, San Diego

European Commission

Sapienza Universit? di Roma

Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases

Ministero dell'Universit? e della Ricerca

Istituto Pasteur-Fondazione Cenci Bolognetti

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01898

Reference66 articles.

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4. Biology and pathogenesis of Naegleria fowleri

5. Center for Disease Control and Prevention. Naegleria fowleri - Primary Amebic Meningoencephalitis (PAM) - Amebic Encephalitis. https://www.cdc.gov/parasites/naegleria/. (accessed October 13rd, 2017).