Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312-Reference-Cited by-同舟云学术

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Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312

Published:2023-12-26 Issue:1 Volume:67 Page:380-401
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Temal-Laib Taouès¹,Peixoto Christophe¹,Desroy Nicolas¹^ORCID,De Lemos Elsa¹,Bonnaterre Florence¹^ORCID,Bienvenu Natacha¹,Picolet Olivier¹,Sartori Eric¹,Bucher Denis¹,López-Ramos Miriam¹,Roca Magadán Carlos¹,Laenen Wendy²,Flower Thomas¹,Mollat Patrick¹,Bugaud Olivier¹,Touitou Robert¹,Pereira Fernandes Anna²,Lavazais Stephanie¹,Monjardet Alain¹,Borgonovi Monica¹,Gosmini Romain¹,Brys Reginald²,Amantini David¹,De Vos Steve²^ORCID,Andrews Martin²

Affiliation:

1. Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France

2. Galapagos NV, Generaal De Wittelaan L11, A3, 2800 Mechelen, Belgium

Funder

Gal?pagos

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01428

Reference36 articles.

1. Nuts and bolts of the salt-inducible kinases (SIKs)

2. Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential

3. Unmet Medical Needs in Ulcerative Colitis: An Expert Group Consensus

4. Unmet needs in inflammatory bowel disease

5. The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions

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