Recent Progress and Prospects of Small Molecules for NLRP3 Inflammasome Inhibition

Author:

Li Na1ORCID,Zhang Ruijia1,Tang Minghai1,Zhao Min2ORCID,Jiang Xueqin1,Cai Xiaoying1,Ye Neng1,Su Kaiyue1,Peng Jing1,Zhang Xinlu1,Wu Wenshuang3,Ye Haoyu1ORCID

Affiliation:

1. Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China

2. Laboratory of Metabolomics and Drug-Induced Liver Injury, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China

3. Division of Thyroid Surgery, Department of General Surgery and Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China

Funder

Sichuan University

West China Hospital, Sichuan University

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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3. Local Scaffold Diversity-Contributed Generator for Discovering Potential NLRP3 Inhibitors;Journal of Chemical Information and Modeling;2024-01-23

4. Discovery of Potent, Orally Bioavailable, Tricyclic NLRP3 Inhibitors;Journal of Medicinal Chemistry;2024-01-04

5. The NLRP3 Inflammasome as a Pathogenic Player Showing Therapeutic Potential in Rheumatoid Arthritis and Its Comorbidities: A Narrative Review;International Journal of Molecular Sciences;2024-01-03

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