Discovery of Orally Available and Brain Penetrant AEP Inhibitors-Reference-Cited by-同舟云学术

Discovery of Orally Available and Brain Penetrant AEP Inhibitors

Published:2023-12-13 Issue:24 Volume:66 Page:17026-17043
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Krummenacher Daniela¹,He Weiping²,Kuhn Bernd¹^ORCID,Schnider Christian¹,Beurier Angélica¹,Brom Virginie¹,Sivasothy Thulase¹,Marty Christine¹^ORCID,Tosstorff Andreas¹^ORCID,Hewings David S.¹^ORCID,Mesch Stefanie¹,Pinard Emmanuel¹,Brändlin Mathis¹^ORCID,Hochstrasser Remo¹,Westwood Paul¹,Rothe Judith¹,Kronenberger Alexandra¹,Morandi Federica¹,Gutbier Simon¹,Schuler Angelika¹,Heer Dominik¹^ORCID,Gloria Ludivine Esteves¹,Joedicke Lisa¹,Rudolph Markus G.¹^ORCID,Müller Lutz¹,Grüninger Fiona¹,Baumann Karlheinz¹,Kaniyappan Senthilvelrajan¹,Manevski Nenad¹^ORCID,Bartels Björn¹^ORCID

Affiliation:

1. Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland

2. WuXi AppTec (Wuhan) Co. Ltd., Wuhan East Lake High-Tech Development Zone, 666 GaoXin Road, Wuhan, Hubei 430075, China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01804

Reference50 articles.

1. Tau strains shape disease

2. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

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