Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate-Reference-Cited by-同舟云学术

Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate

Published:2024-01-31 Issue: Volume: Page:
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Belle Roman¹²,Saraç Hilal¹²³,Salah Eidarus¹⁴,Bhushan Bhaskar¹³,Szykowska Aleksandra⁴,Roper Grace¹²,Tumber Anthony¹⁵,Kriaucionis Skirmantas⁶,Burgess-Brown Nicola⁴,Schofield Christopher J.¹⁵^ORCID,Brown Tom¹^ORCID,Kawamura Akane¹²³^ORCID

Affiliation:

1. Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, OX1 3TA Oxford, United Kingdom

2. Chemistry − School of Natural and Environmental Sciences, Bedson Building, Newcastle University, NE1 7RU Newcastle upon Tyne, United Kingdom

3. Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, OX3 7BN Oxford, United Kingdom

4. Centre for Medicines Discovery, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, OX3 7DQ Oxford, United Kingdom

5. Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, OX1 3TA Oxford, United Kingdom

6. Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, OX3 7DQ Oxford, United Kingdom

Funder

Engineering and Physical Sciences Research Council

NIHR Oxford Biomedical Research Centre

Ludwig Institute for Cancer Research

Wellcome Trust

H2020 European Research Council

Cancer Research UK

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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