Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer-Reference-Cited by-同舟云学术

Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer

Published:2019-02-18 Issue:5 Volume:62 Page:2651-2665
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shouksmith Andrew E.¹,Shah Fenil,Grimard Michelle L.,Gawel Justyna M.¹,Raouf Yasir S.¹,Geletu Mulu¹,Berger-Becvar Angelika¹,de Araujo Elvin D.¹,Luchman H. Artee²,Heaton William L.³,Bakhshinyan David⁴,Adile Ashley A.⁴,Venugopal Chitra⁴,O’Hare Thomas³,Deininger Michael W.³,Singh Sheila K.⁴,Konieczny Stephen F.⁵,Weiss Samuel²,Fishel Melissa L.,Gunning Patrick T.¹^ORCID

Affiliation:

1. Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, Ontario L5L 1C6, Canada

2. Hotchkiss Brain Institute and Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta T2N 1N4, Canada

3. Huntsman Cancer Institute, Division of Hematology and Hematologic Malignancies, University of Utah, Salt Lake City, Utah 84112, United States

4. McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario L8S 4L8, Canada

5. Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, United States

Funder

University of Toronto

Leukemia and Lymphoma Society of Canada

Indiana Clinical and Translational Sciences Institute

Stem Cell Network

Natural Sciences and Engineering Research Council of Canada

Alberta Innovates - Health Solutions

Mitacs

National Cancer Institute

Jeff Gordon Children?s Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01957

Reference51 articles.

1. Current and Emerging Therapies in Metastatic Pancreatic Cancer

2. Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

3. Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

4. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

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