Novel Hypoxia-Inducible Factor 1α (HIF-1α) Inhibitors for Angiogenesis-Related Ocular Diseases: Discovery of a Novel Scaffold via Ring-Truncation Strategy

Author:

An Hongchan1ORCID,Lee Seungbeom1,Lee Jung Min1,Jo Dong Hyun2,Kim Joohwan3,Jeong Yoo-Seong1,Heo Mi Jeong1,Cho Chang Sik2,Choi Hoon1,Seo Ji Hae1,Hwang Seyeon1,Lim Jihye1,Kim Taewoo1,Jun Hyoung Oh2,Sim Jaehoon14,Lim Changjin14,Hur Joonseong1,Ahn Jungmin1,Kim Hyun Su14,Seo Seung-Yong5,Na Younghwa4,Kim Seok-Ho4,Lee Jeewoo1ORCID,Lee Jeeyeon1ORCID,Chung Suk-Jae1,Kim Young-Myeong3,Kim Kyu-Won1,Kim Sang Geon1,Kim Jeong Hun26,Suh Young-Ger14ORCID

Affiliation:

1. College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea

2. Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul 03080, Republic of Korea

3. Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Gangwon-do 24341, Republic of Korea

4. College of Pharmacy, CHA University, Gyeonggi-do 11160, Republic of Korea

5. College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea

6. Department of Ophthalmology, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea

Funder

National Research Foundation of Korea

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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