Development of 1-((1,4-trans)-4-Aryloxycyclohexyl)-3-arylurea Activators of Heme-Regulated Inhibitor as Selective Activators of the Eukaryotic Initiation Factor 2 Alpha (eIF2α) Phosphorylation Arm of the Integrated Endoplasmic Reticulum Stress Response

Author:

Yefidoff-Freedman Revital1,Fan Jing12,Yan Lu1,Zhang Qingwen13ORCID,dos Santos Guillermo Rodrigo Reis1,Rana Sandeep4,Contreras Jacob I.4,Sahoo Rupam1,Wan Debin5,Young Jun5,Dias Teixeira Karina Luiza1,Morisseau Christophe5,Halperin Jose1,Hammock Bruce5ORCID,Natarajan Amarnath4,Wang Peimin2,Chorev Michael1,Aktas Bertal H.1ORCID

Affiliation:

1. Hematology Laboratory for Translational Research, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, United States

2. Department of Orthopedics, Jiangsu Province Hospital of TCM, Nanjing University of Chinese Medicine, 155 Hanzhong Road, Nanjing, Jiangsu 210029, China

3. Division of Medicinal and Process Chemistry, Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai 200437, China

4. Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States

5. Department of Entomology and Nematology, University of California Davis Comprehensive Cancer Center, University of California, One Shields Avenue, Davis, California 95616, United States

Funder

U.S. Department of Health and Human Services

Science and Technology Commission of Shanghai Municipality

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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