A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate-Reference-Cited by-同舟云学术

A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate

Published:2017-12-20 Issue:1 Volume:61 Page:207-223
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chrovian Christa C.¹^ORCID,Soyode-Johnson Akinola¹,Peterson Alexander A.¹,Gelin Christine F.¹,Deng Xiaohu¹,Dvorak Curt A.¹,Carruthers Nicholas I.¹,Lord Brian¹,Fraser Ian¹,Aluisio Leah¹,Coe Kevin J.¹,Scott Brian¹,Koudriakova Tatiana¹,Schoetens Freddy¹,Sepassi Kia¹,Gallacher David J.²,Bhattacharya Anindya¹,Letavic Michael A.¹^ORCID

Affiliation:

1. Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121, United States

2. Janssen Research & Development, Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01279

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1. The role of the innate immune system in psychiatric disorders

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