Targeting Cysteine Located Outside the Active Site: An Effective Strategy for Covalent ALKi Design-Reference-Cited by-全球学者库

Targeting Cysteine Located Outside the Active Site: An Effective Strategy for Covalent ALKi Design

Published:2021-01-20 Issue:3 Volume:64 Page:1558-1569
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yan Guoyi¹²^ORCID,Zhong Xinxin¹,Pu Chunlan¹^ORCID,Yue Lin¹,Shan Huifang¹,Lan Suke¹,Zhou Meng³,Hou Xueyan⁴,Yang Jie¹,Li Deyu²,Fan Shilong⁵,Li Rui¹

Affiliation:

1. State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Chengdu, 610041, China

2. Department of Hepatobiliary Pancreatic Surgery, Henan Provincial People’s Hospital, Zhengzhou, 450000, China

3. Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Ministry of Education & State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550000, China

4. College of Pharmacy, Xinxiang Medical University, Xinxiang, 453000, China

5. The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua University, Beijing, 100000, China

Funder

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01707

Reference29 articles.

1. Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer

2. Novel ALK inhibitors in clinical use and development

3. Concomitant EML4-ALK rearrangement and EGFR mutation in non-small cell lung cancer patients: a literature review of 100 cases