Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties-Reference-Cited by-同舟云学术

Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties

Published:2020-04-15 Issue:9 Volume:63 Page:4837-4848
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kang Dongwei¹²^ORCID,Feng Da¹,Sun Yanying¹,Fang Zengjun¹³,Wei Fenju¹,De Clercq Erik⁴^ORCID,Pannecouque Christophe⁴,Liu Xinyong¹²^ORCID,Zhan Peng¹²^ORCID

Affiliation:

1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, P.R. China

2. China−Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012 Jinan, Shandong, PR China

3. The Second Hospital of Shandong University, No. 247 Beiyuan Avenue, 250033 Jinan, Shandong, P.R. China

4. Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U. Leuven, Herestraat 49 Postbus 1043 (09.A097), B-3000 Leuven, Belgium

Funder

China Postdoctoral Science Foundation

Taishan Scholar Project of Shandong Province

Shandong University

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Shandong Provincial Key research and development Project

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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