Conformational Strain of Macrocyclic Peptides in Ligand–Receptor Complexes Based on Advanced Refinement of Bound-State Conformers-Reference-Cited by-同舟云学术

Conformational Strain of Macrocyclic Peptides in Ligand–Receptor Complexes Based on Advanced Refinement of Bound-State Conformers

Published:2021-03-16 Issue:6 Volume:64 Page:3282-3298
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Brueckner Alexander C.¹^ORCID,Deng Qiaolin¹^ORCID,Cleves Ann E.²^ORCID,Lesburg Charles A.³^ORCID,Alvarez Juan C.³,Reibarkh Mikhail Y.⁴^ORCID,Sherer Edward C.⁴^ORCID,Jain Ajay N.²^ORCID

Affiliation:

1. Computational & Structural Chemistry, Merck & Co Inc, 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

2. Bioengineering and Therapeutic Sciences, University of California San Francisco, Box 0128, San Francisco, California 94158, United States

3. Computational and Structural Chemistry, Merck and Co Inc, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States

4. Analytical Research and Development, Merck & Co Inc, 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c02159

Reference82 articles.

1. Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

2. Protein-Protein Interactions in Receptor Activation and Intracellular Signalling

3. Small-molecule protein-protein interaction inhibitors: Therapeutic potential in light of molecular size, chemical space, and ligand binding efficiency considerations

4. The Future of Peptide-based Drugs

5. The druggable genome

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