Berberine Directly Targets the NEK7 Protein to Block the NEK7–NLRP3 Interaction and Exert Anti-inflammatory Activity
Author:
Affiliation:
1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Funder
Ministry of Science and Technology of the People's Republic of China
Chinese Academy of Medical Sciences
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01743
Reference55 articles.
1. Learning from berberine: Treating chronic diseases through multiple targets
2. Metabolic effects of berberine on liver phosphatidate phosphohydrolase in rats fed on high lipogenic diet: an additional mechanism for the hypolipidemic effects of berberine
3. Synthesis and Identification of Novel Berberine Derivatives as Potent Inhibitors against TNF-α-Induced NF-κB Activation
4. Cardiovascular Actions of Berberine
5. Berberine reduces insulin resistance through protein kinase C–dependent up-regulation of insulin receptor expression
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