Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity-Reference-Cited by-同舟云学术

Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity

Published:2020-08-05 Issue:17 Volume:63 Page:9228-9236
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Etayash Hashem¹^ORCID,Pletzer Daniel¹²^ORCID,Kumar Prashant³,Straus Suzana K.³^ORCID,Hancock Robert E. W.¹

Affiliation:

1. Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, 2259 Lower Mall Research Station, Vancouver V6T 1Z4, British Columbia, Canada

2. Department of Microbiology and Immunology, University of Otago, 720 Cumberland Street, Dunedin 9054, New Zealand

3. Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver V6T 1Z1, British Columbia, Canada

Funder

Canadian Institutes of Health Research

Killam Trusts

Canada Research Chairs

Cystic Fibrosis Foundation

Natural Sciences and Engineering Research Council of Canada

Michael Smith Foundation for Health Research

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00303

Reference46 articles.

1. Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials

2. Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies

3. Cationic Amphiphiles Induce Macromolecule Denaturation and Organelle Decomposition in Pathogenic Yeast

4. Antibiofilm Peptides: Potential as Broad-Spectrum Agents

5. The immunology of host defence peptides: beyond antimicrobial activity

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