Betulonic Acid Derivatives Interfering with Human Coronavirus 229E Replication via the nsp15 Endoribonuclease

Author:

Stevaert Annelies1ORCID,Krasniqi Besir2,Van Loy Benjamin1,Nguyen Tien3,Thomas Joice2ORCID,Vandeput Julie1,Jochmans Dirk1,Thiel Volker45,Dijkman Ronald456,Dehaen Wim2,Voet Arnout3ORCID,Naesens Lieve1ORCID

Affiliation:

1. Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven, 3000 Leuven, Belgium

2. Molecular Design and Synthesis, Department of Chemistry, KU Leuven, 3001 Leuven, Belgium

3. Biochemistry, Molecular and Structural Biology, Department of Chemistry, KU Leuven, 3001 Leuven, Belgium

4. Institute of Virology and Immunology (IVI), 3012 Bern and 3012 Bern, Switzerland

5. Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland

6. Institute for Infectious Diseases (IFIK), University of Bern, 3012 Bern, Switzerland

Funder

European Commission

KU Leuven

Innovative Medicines Initiative

Fonds Wetenschappelijk Onderzoek

Fundaci? la Marat? de TV3

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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