Selexipag: An Oral and Selective IP Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension
Author:
Affiliation:
1. Discovery Research Laboratories, Nippon Shinyaku Co., Ltd., 14 Nishinosho-Monguchi-Cho, Kisshoin, Minami-ku, Kyoto 601-8550, Japan
2. Drug Discovery Department, Actelion Pharmaceuticals Ltd., Gewerbestrasse 16, Allschwil CH4123, Switzerland
Funder
Actelion Pharmaceuticals Ltd
Nippon Shinyaku Co., Ltd.
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00698
Reference50 articles.
1. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
2. Cardioprotective prostacyclin signaling in vascular smooth muscle
3. Prostacyclin Synthase Expression Is Decreased in Lungs from Patients with Severe Pulmonary Hypertension
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