Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymerase-1/2 Inhibitor, as an Anticancer Agent
Author:
Affiliation:
1. BioMarin Pharmaceutical Inc., 105 Digital Drive, Novato, California 94949, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01498
Reference45 articles.
1. The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases
2. PARP inhibition: PARP1 and beyond
3. Therapeutic applications of PARP inhibitors: Anticancer therapy and beyond
4. The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets
5. PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis
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