Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist-Reference-Cited by-同舟云学术

Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist

Published:2015-10-07 Issue:20 Volume:58 Page:8128-8140
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

De Savi Chris¹²,Bradbury Robert H.¹,Rabow Alfred A.¹,Norman Richard A.³,de Almeida Camila¹,Andrews David M.¹,Ballard Peter¹,Buttar David¹,Callis Rowena J.³,Currie Gordon S.¹,Curwen Jon O.¹,Davies Chris D.¹,Donald Craig S.¹,Feron Lyman J. L.¹,Gingell Helen³,Glossop Steven C.¹,Hayter Barry R.¹,Hussain Syeed³,Karoutchi Galith¹,Lamont Scott G.¹,MacFaul Philip¹,Moss Thomas A.¹,Pearson Stuart E.¹,Tonge Michael³,Walker Graeme E.³,Weir Hazel M.¹,Wilson Zena¹

Affiliation:

1. Oncology iMed, AstraZeneca, Mereside, Alderley Park, Macclesfield SK10 4TG, U.K.

2. Oncology iMed, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States

3. Discovery Sciences, AstraZeneca, Mereside, Alderley Park, Macclesfield SK10 4TG, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00984

Reference50 articles.

1. Tamoxifen: a most unlikely pioneering medicine