Novel Strategy To Inhibit Transthyretin Amyloidosis via the Synergetic Effect of Chemoselective Acylation and Noncovalent Inhibitor Release-Reference-Cited by-同舟云学术

Novel Strategy To Inhibit Transthyretin Amyloidosis via the Synergetic Effect of Chemoselective Acylation and Noncovalent Inhibitor Release

Published:2023-02-07 Issue:4 Volume:66 Page:2893-2903
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lee Seok Beom¹,Yu Jaeni¹,Kim Hyunwoo²,Kim Kun Woo¹,Jeong Jong Woo¹,Kim Yun Lan¹,Park Sung Jean³,Koo Tae-Sung¹,Lee Changwook²^ORCID,Hong Ki Bum⁴^ORCID,Choi Sungwook¹^ORCID

Affiliation:

1. Graduate School of New Drug Discovery and Development, Chungnam National University, Daejon 34134, Republic of Korea

2. Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea

3. College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, Republic of Korea

4. New Drug Development Center (NDDC), Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Republic of Korea

Funder

National Research Foundation of Korea

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01926

Reference64 articles.

1. Irreversible Protein Kinase Inhibitors: Balancing the Benefits and Risks

2. Targeted Covalent Inhibitors for Drug Design

3. Emerging and Re-Emerging Warheads for Targeted Covalent Inhibitors: Applications in Medicinal Chemistry and Chemical Biology

4. Discovery of Cysteine-targeting Covalent Protein Kinase Inhibitors

5. Cysteine Function Governs Its Conservation and Degeneration and Restricts Its Utilization on Protein Surfaces

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