<i>N</i>′-Phenylacetohydrazide Derivatives as Potent Ebola Virus Entry Inhibitors with an Improved Pharmacokinetic Profile-Reference-Cited by-同舟云学术

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N′-Phenylacetohydrazide Derivatives as Potent Ebola Virus Entry Inhibitors with an Improved Pharmacokinetic Profile

Published:2023-04-06 Issue:8 Volume:66 Page:5465-5483
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Garcia-Rubia Alfonso¹,Lasala Fátima²,Ginex Tiziana¹,Morales-Tenorio Marcos¹,Olal Catherine³,Heung Michelle³,Oquist Paola⁴,Galindo Inmaculada⁵,Cuesta-Geijo Miguel Ángel⁵,Casasnovas José M.⁶,Campillo Nuria E.¹⁷^ORCID,Canales Ángeles⁴^ORCID,Alonso Covadonga⁵,Martínez Ana¹^ORCID,Muñoz-Fontela César³,Delgado Rafael²,Gil Carmen¹^ORCID

Affiliation:

1. Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), Madrid 28040, Spain

2. Instituto de Investigación Hospital 12 de Octubre, Madrid 28041, Spain

3. Bernhard Nocht Institute for Tropical Medicine, Hamburg 20359, Germany

4. Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Madrid 28040, Spain

5. Dpt. Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Madrid 28040, Spain

6. Centro Nacional de Biotecnología (CNB-CSIC), Madrid 28049, Spain

7. Instituto de Ciencias Matemáticas (ICMAT-CSIC), Madrid 28049, Spain

Funder

European Commission

Agencia Estatal de Investigaci?n

Ministerio de Ciencia e Innovaci?n

?la Caixa? Foundation

Horizon 2020 Framework Programme

Instituto de Salud Carlos III

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01785

Reference41 articles.

1. Ebola outbreaks: A stress test of the preparedness of medicines regulatory systems for public health crises

2. Ebola virus disease

3. New filovirus disease classification and nomenclature

4. Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

5. Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

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