Screening of σ2 Receptor Ligands and In Vivo Evaluation of 11C-Labeled 6,7-Dimethoxy-2-[4-(4-methoxyphenyl)butan-2-yl]-1,2,3,4-tetrahydroisoquinoline for Potential Use as a σ2 Receptor Brain PET Tracer-Reference-Cited by-同舟云学术

Screening of σ₂ Receptor Ligands and In Vivo Evaluation of ¹¹C-Labeled 6,7-Dimethoxy-2-[4-(4-methoxyphenyl)butan-2-yl]-1,2,3,4-tetrahydroisoquinoline for Potential Use as a σ₂ Receptor Brain PET Tracer

Published:2022-04-11 Issue:8 Volume:65 Page:6261-6272
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kim Ho Young¹^ORCID,Lee Ji Youn¹,Hsieh Chia-Ju¹^ORCID,Riad Aladdin¹^ORCID,Izzo Nicholas J.²^ORCID,Catalano Susan M.²,Graham Thomas J. A.¹,Mach Robert H.¹^ORCID

Affiliation:

1. Department of Radiology, University of Pennsylvania, Vagelos Laboratories, 1012, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States

2. Cognition Therapeutics Inc., Pittsburgh, Pennsylvania 15203-5118, United States

Funder

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00191

Reference57 articles.

1. Sigma receptors mediate the psychotomimetic effects of N-allylnormetazocine (SKF-10,047), but not its opioid agonistic-antagonistic properties

2. A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain