The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation-Reference-Cited by-同舟云学术

The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation

Published:2022-08-31 Issue:18 Volume:65 Page:11927-11948
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Regueiro-Ren Alicia¹^ORCID,Sit Sing-Yuen²,Chen Yan²,Chen Jie²,Swidorski Jacob J.²,Liu Zheng²,Venables Brian L.²,Sin Ny²,Hartz Richard A.²^ORCID,Protack Tricia³,Lin Zeyu³,Zhang Sharon³,Li Zhufang³,Wu Dauh-Rurng⁴,Li Peng⁴,Kempson James⁴,Hou Xiaoping⁴^ORCID,Gupta Anuradha⁵^ORCID,Rampulla Richard⁴,Mathur Arvind⁴,Park Hyunsoo⁶,Sarjeant Amy⁶^ORCID,Benitex Yulia⁷,Rahematpura Sandhya⁷,Parker Dawn⁷,Phillips Thomas⁷,Haskell Roy⁷,Jenkins Susan⁷,Santone Kenneth S.⁷,Cockett Mark³,Hanumegowda Umesh⁷,Dicker Ira³,Meanwell Nicholas A.¹^ORCID,Krystal Mark³

Affiliation:

1. Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, Princeton, New Jersey08543, United States

2. Department of Discovery Chemistry, Bristol Myers Squibb Research and Early Development, 5 Research Parkway, Wallingford, Connecticut06492, United States

3. Department of Virology, Bristol Myers Squibb Research and Early Development, 5 Research Parkway, Wallingford, Connecticut06492, United States

4. Department of Discovery Synthesis, Bristol Myers Squibb Research and Early Development, PO Box 4000, Princeton, New Jersey08543, United States

5. Department of Discovery Synthesis; Bristol Myers Squibb Research and Early Development, Bangalore 560099, India

6. Bristol Myers Squibb Chemical and Synthetic Development, New Brunswick, New Jersey08901, United States

7. Department of Pharmaceutical Candidate Optimization, Bristol Myers Squibb Research and Early Development, 5 Research Parkway, Wallingford, Connecticut06492, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00879

Reference103 articles.

1. Betulinic Acid and Dihydrobetulinic Acid Derivatives as Potent Anti-HIV Agents

2. Bevirimat: A Novel Maturation Inhibitor for the Treatment of HIV-1 Infection

3. Anti-Human Immunodeficiency Virus Activity of YK-FH312 (a Betulinic Acid Derivative), a Novel Compound Blocking Viral Maturation

4. PA-457: A potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing

5. Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Replication by Specific Targeting of the Final Step of Virion Maturation

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