Synthesis, Structure–Activity Relationships, and <i>In Vivo</i> Evaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity-Reference-Cited by-同舟云学术

Synthesis, Structure–Activity Relationships, and In Vivo Evaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity

Published:2022-11-28 Issue:23 Volume:65 Page:15935-15966
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hartz Richard A.¹^ORCID,Xu Li¹^ORCID,Sit Sing-Yuen¹,Chen Jie¹,Venables Brian L.¹,Lin Zeyu²,Zhang Sharon²,Li Zhufang²,Parker Dawn³,Simmons Tara S.³,Jenkins Susan³,Hanumegowda Umesh M.³,Dicker Ira²,Krystal Mark²,Meanwell Nicholas A.¹^ORCID,Regueiro-Ren Alicia¹^ORCID

Affiliation:

1. Department of Small Molecule Drug Discovery, Bristol Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, Connecticut06492, United States

2. Department of Virology, Bristol Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, Connecticut06492, United States

3. Department of Metabolism and Pharmacokinetics, Bristol Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, Connecticut06492, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01618

Reference65 articles.

1. HIV.gov website. https://www.hiv.gov/hiv-basics/overview/data-and-trends/global-statistics

2. HIV.gov website. https://www.hiv.gov/hiv-basics/overview/data-and-trends/statistics

3. Antiretroviral therapy and management of HIV infection

4. Antiretroviral Therapy

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