Discovery of a Potent and Highly Selective Dipeptidyl Peptidase IV and Carbonic Anhydrase Inhibitor as “Antidiabesity” Agents Based on Repurposing and Morphing of WB-4101-Reference-Cited by-同舟云学术

Discovery of a Potent and Highly Selective Dipeptidyl Peptidase IV and Carbonic Anhydrase Inhibitor as “Antidiabesity” Agents Based on Repurposing and Morphing of WB-4101

Published:2022-10-06 Issue:20 Volume:65 Page:13946-13966
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Artasensi Angelica¹^ORCID,Angeli Andrea²^ORCID,Lammi Carmen¹^ORCID,Bollati Carlotta¹,Gervasoni Silvia¹³,Baron Giovanna¹,Matucci Rosanna⁴,Supuran Claudiu T.²^ORCID,Vistoli Giulio¹^ORCID,Fumagalli Laura¹

Affiliation:

1. Department of Pharmaceutical Sciences “DISFARM”, Università degli Studi di Milano, via Mangiagalli 25, I-20133 Milan, Italy

2. Department of Pharmaceutical Sciences “NEUROFARBA”, University of Florence, via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy

3. Department of Physics, Citt. Universitaria, University of Cagliari, I-09042 Cagliari, Monserrato, Italy

4. Department of Pharmacology and Toxicology “NEUROFARBA”, University of Florence, Viale Pieraccini 6, 50134 Florence, Italy

Funder

Università degli Studi di Milano

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01192

Reference50 articles.

1. Prevalence, incidence and mortality of type 1 and type 2 diabetes in Denmark 1996–2016

2. Epidemiology of Type 2 Diabetes – Global Burden of Disease and Forecasted Trends

3. Biochemistry and molecular cell biology of diabetic complications

4. Diabesity: the combined burden of obesity and diabetes on heart disease and the role of imaging

5. Obesity management as a primary treatment goal for type 2 diabetes: time to reframe the conversation

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