Strategies for Assessing Acceptable Intakes for Novel <i>N</i>-Nitrosamines Derived from Active Pharmaceutical Ingredients-Reference-Cited by-同舟云学术

Strategies for Assessing Acceptable Intakes for Novel N-Nitrosamines Derived from Active Pharmaceutical Ingredients

Published:2022-11-28 Issue:23 Volume:65 Page:15584-15607
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ponting David J.¹^ORCID,Dobo Krista L.²^ORCID,Kenyon Michelle O.²,Kalgutkar Amit S.³^ORCID

Affiliation:

1. Lhasa Limited, Granary Wharf House, 2 Canal Wharf, Leeds LS11 5PS, United Kingdom

2. Drug Safety Research and Development, Global Portfolio and Regulatory Strategy, Pfizer Worldwide Research, Development, and Medical, Eastern Point Road, Groton, Connecticut 06340, United States

3. Medicine Design, Pfizer Worldwide Research, Development, and Medical, 1 Portland Street, Cambridge, Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01498

Reference165 articles.

1. A tiered approach to threshold of regulation

2. Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet

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