Synthesis and Characterization of NUC-7738, an Aryloxy Phosphoramidate of 3′-Deoxyadenosine, as a Potential Anticancer Agent-Reference-Cited by-同舟云学术

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Synthesis and Characterization of NUC-7738, an Aryloxy Phosphoramidate of 3′-Deoxyadenosine, as a Potential Anticancer Agent

Published:2022-11-23 Issue:23 Volume:65 Page:15789-15804
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Serpi Michaela¹^ORCID,Ferrari Valentina²,McGuigan Christopher²,Ghazaly Essam³,Pepper Chris⁴

Affiliation:

1. School of Chemistry, Cardiff University Main Building, Park Place, Cardiff CF10 3AT, Wales, U.K.

2. School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, King Edward VII Avenue, Cardiff CF10 3NB, U.K.

3. Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, U.K.

4. Brighton and Sussex Medical School, University of Sussex, Brighton BN1 9PX, U.K.

Funder

NuCana

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01348

Reference74 articles.

1. Cordyceps – A traditional Chinese medicine and another fungal therapeutic biofactory?

2. Cordycepin: A bioactive metabolite with therapeutic potential

3. Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin

4. Cordyceps Mushroom: A Potent Anticancer Nutraceutical

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1. Design, synthesis and biological evaluation of aryloxy thiophosphoramidate triesters of anticancer nucleoside analogues;Bioorganic & Medicinal Chemistry;2024-04

2. 3′-Deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome;Neural Regeneration Research;2024-01-26

3. Is it still worth renewing nucleoside anticancer drugs nowadays?;European Journal of Medicinal Chemistry;2024-01

4. Design, synthesis, antibacterial/antitumor activity and in vitro stability of novel cordycepin derivatives with unsaturated fatty acid chain;European Journal of Pharmaceutical Sciences;2023-08

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