Design, Synthesis, and Evaluation of Lung-Retentive Prodrugs for Extending the Lung Tissue Retention of Inhaled Drugs-Reference-Cited by-同舟云学术

Design, Synthesis, and Evaluation of Lung-Retentive Prodrugs for Extending the Lung Tissue Retention of Inhaled Drugs

Published:2022-07-07 Issue:14 Volume:65 Page:9802-9818
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ayre Jack¹^ORCID,Redmond Joanna M.²^ORCID,Vitulli Giovanni²,Tomlinson Laura²,Weaver Richard³,Comeo Eleonora¹,Bosquillon Cynthia⁴^ORCID,Stocks Michael J.¹^ORCID

Affiliation:

1. School of Pharmacy, Biodiscovery Institute, University Park Nottingham, Nottingham NG7 2RD, U.K.

2. GSK Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.

3. XenoGesis Ltd, Discovery Building, BioCity, Pennyfoot Street, Nottingham NG1 1GR, U.K.

4. School of Pharmacy, Boots Science Building, University Park Nottingham, Nottingham NG7 2RD, U.K.

Funder

Engineering and Physical Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00416

Reference31 articles.

1. Inhaling medicines: delivering drugs to the body through the lungs

2. An update on the use of inhaled therapy in COPD

3. The Position of Inhaled Chemotherapy in the Care of Patients with Lung Tumors: Clinical Feasibility and Indications According to Recent Pharmaceutical Progresses

4. Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis

5. Inhaled Antibiotic Therapy in Chronic Respiratory Diseases

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