Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation-Reference-Cited by-同舟云学术

Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation

Published:2022-10-28 Issue:21 Volume:65 Page:14673-14691
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pinheiro Francisca¹,Pallarès Irantzu¹^ORCID,Peccati Francesca²^ORCID,Sánchez-Morales Adrià²,Varejão Nathalia¹,Bezerra Filipa³⁴,Ortega-Alarcon David⁵⁶⁷,Gonzalez Danilo²,Osorio Marcelo²,Navarro Susanna¹^ORCID,Velázquez-Campoy Adrián⁵⁶⁷^ORCID,Almeida Maria Rosário³⁴,Reverter David¹,Busqué Félix²,Alibés Ramon²^ORCID,Sodupe Mariona²^ORCID,Ventura Salvador¹⁸^ORCID

Affiliation:

1. Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona 08193, Spain

2. Departament de Química, Universitat Autònoma de Barcelona, Bellaterra, Barcelona 08193, Spain

3. Molecular Neurobiology Group, i3S−Instituto de Investigação e Inovação em Saúde, IBMC−Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal

4. Departamento de Biologia Molecular, ICBAS−Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal

5. Department of Biochemistry and Molecular & Cellular Biology, and Institute for Biocomputation eand Physics of Complex Systems (BIFI), Joint Unit GBsC-CSIC-BIFI, Universidad de Zaragoza, 50018 Zaragoza, Spain

6. Aragon Institute for Health Research, 50009 Zaragoza, Spain

7. Biomedical Research Network Center in Hepatic and Digestive Diseases (CIBERehd), 28029 Madrid, Spain

8. ICREA, Passeig Lluis Companys 23, E-08010 Barcelona, Spain

Funder

European Regional Development Fund

Ministerio de Econom?a y Competitividad

Universitat Aut?noma de Barcelona

Funda??o para a Ci?ncia e a Tecnologia

Instituci? Catalana de Recerca i Estudis Avan?ats

Agencia Estatal de Investigaci?n,Ministerio de Ciencia, Innovaci?n y Universidades

Publisher

American Chemical Society (ACS)