Crystallography-Guided Optimizations of the Keap1–Nrf2 Inhibitors on the Solvent Exposed Region: From Symmetric to Asymmetric Naphthalenesulfonamides-Reference-Cited by-同舟云学术

Crystallography-Guided Optimizations of the Keap1–Nrf2 Inhibitors on the Solvent Exposed Region: From Symmetric to Asymmetric Naphthalenesulfonamides

Published:2022-06-10 Issue:12 Volume:65 Page:8289-8302
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Guodong¹,Hou Ruilin¹,Xu Lijuan²,Zhang Xinqi¹,Yan Jianyu²,Xing Chengguo³^ORCID,Xu Ke⁴⁵,Zhuang Chunlin¹²^ORCID

Affiliation:

1. School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China

2. School of Pharmacy, Second Military Medical University, Shanghai 200433, China

3. Department of Medicinal Chemistry, University of Florida, 1345 Center Drive, Gainesville, Florida 32610, United States

4. Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai 200434, China

5. Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Shanghai 200434, China

Funder

Ministry of Science and Technology of the People's Republic of China

Second Military Medical University

Shanghai Municipal Education Commission

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Tongji University

Recruitment Program of Global Experts

Key Research and Development Program of Ningxia

Shanghai Health Commission Clinical Research Special Youth Project

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00170

Reference58 articles.

1. Circulating protein carbonyls are specifically elevated in critically ill patients with pneumonia relative to other sources of sepsis

2. Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

3. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

4. Direct and indirect antioxidant properties of inducers of cytoprotective proteins

5. Transcriptional regulation of the rat NAD(P)H:quinone reductase gene

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