Novel Indole–Chalcone Derivative-Ligated Platinum(IV) Prodrugs Attenuate Cisplatin Resistance in Lung Cancer through ROS/ER Stress and Mitochondrial Dysfunction

Author:

Liu Zhikun1,Wang Meng12,Huang Rizhen3,Hu Tianhui4,Jing Yi1,Huang Xiaochao1,Hu Weiwei1,Cao Guoxiu1,Wang Hengshan2ORCID

Affiliation:

1. Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huai’an 223003, China

2. State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, China

3. Guangxi Key Laboratory for Pharmaceutical Molecular Discovery and Druggability Optimization, School of Pharmacy, Guilin Medical University, Guilin 541199, China

4. Traditional Chinese Medicine Department, Huai’an Maternal and Child Health-Care Center, Huai’an 2230003, China

Funder

Huaiyin Institute of Technology

Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research

National Natural Science Foundation of China

Natural Science Foundation of the Jiangsu Higher Education Institutions of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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