Discovery of Anthranilic Acid Derivatives as Difluoromethylornithine Adjunct Agents That Inhibit Far Upstream Element Binding Protein 1 (FUBP1) Function-Reference-Cited by-同舟云学术

Discovery of Anthranilic Acid Derivatives as Difluoromethylornithine Adjunct Agents That Inhibit Far Upstream Element Binding Protein 1 (FUBP1) Function

Published:2022-11-16 Issue:22 Volume:65 Page:15391-15415
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dobrovolskaite Aiste¹,Moots Holly¹,Tantak Mukund P.¹,Shah Kunal¹,Thomas Jenna¹,Dinara Sharifa¹,Massaro Chelsea¹,Hershberger Paul M.²,Maloney Patrick R.²,Peddibhotla Satyamaheshwar²^ORCID,Sugarman Eliot²,Litherland Sally³,Arnoletti Juan Pablo³,Jha Rajiv Kumar⁴,Levens David⁴,Phanstiel Otto¹^ORCID

Affiliation:

1. University of Central Florida, Biomolecular Research Annex, 12722 Research Parkway, Orlando, Florida 32826, United States

2. Sanford Burnham Medical Research Institute, 6400 Sanger Road, Orlando, Florida 32827, United States

3. Advent Health Cancer Institute, 2520 North Orange Ave, Suite 104, Orlando, Florida 32804, United States

4. Laboratory of Pathology, Center for Cancer Research, 10 Center Drive, Building 10, Room 2N106, Bethesda, Maryland 20892-1500, United States

Funder

Florida Department of Health

Sanford-Burnham Medical Research Institute at Lake Nona

College of Medicine, University of Central Florida

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01350

Reference33 articles.

1. An overview of polyamine metabolism in pancreatic ductal adenocarcinoma

2. Investigation of Polyamine Metabolism and Homeostasis in Pancreatic Cancers

3. Polyamine Transport Inhibitors: Design, Synthesis, and Combination Therapies with Difluoromethylornithine

4. A novel polyamine blockade therapy activates an anti-tumor immune response

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