Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G-Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells-Reference-Cited by-同舟云学术

Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G-Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells

Published:2022-09-08 Issue:18 Volume:65 Page:12055-12067
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Marzano Simona¹,Miglietta Giulia²,Morigi Rita²^ORCID,Marinello Jessica²,Arleo Andrea²^ORCID,Procacci Monica²,Locatelli Alessandra²,Leoni Alberto²,Pagano Bruno¹^ORCID,Randazzo Antonio¹^ORCID,Amato Jussara¹^ORCID,Capranico Giovanni²^ORCID

Affiliation:

1. Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy

2. Department of Pharmacy and Biotechnology, Alma Mater Studiorum─University of Bologna, 40126 Bologna, Italy

Funder

Associazione Italiana per la Ricerca sul Cancro

Fondazione Italiana per la Ricerca sul Cancro

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00772

Reference37 articles.

1. Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

2. Quadruplex Nucleic Acids as Novel Therapeutic Targets

3. G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies

4. G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders

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