Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-<i>a</i>]pyridine Structure-Reference-Cited by-同舟云学术

Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure

Published:2023-02-09 Issue:4 Volume:66 Page:2422-2456
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mejdrová Ivana¹,Dušek Jan²,Škach Kryštof¹^ORCID,Stefela Alžbeta²,Skoda Josef²,Chalupský Karel¹³,Dohnalová Klára³⁴,Pavkova Ivona⁵^ORCID,Kronenberger Thales⁶⁷⁸,Rashidian Azam⁶,Smutná Lucie²,Duchoslav Vojtěch¹,Smutny Tomas²,Pávek Petr²,Nencka Radim¹^ORCID

Affiliation:

1. Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic

2. Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Akademika Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic

3. Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech Republic

4. 1st Medical Faculty, Charles University, Katerinska 32, 112 08 Prague, Czech Republic

5. Faculty of Military Health Sciences, University of Defense, Trebeska 1575, 500 01 Hradec Kralove, Czech Republic

6. Department of Internal Medicine VIII, University Hospital of Tübingen, 72076 Tübingen, Germany

7. School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland

8. Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität, 72076 Tübingen, Germany

Funder

Grantov? Agentura Cesk? Republiky

Akademie Ved Cesk? Republiky

Technologick? Agentura Cesk? Republiky

Ministerstvo Obrany Cesk? Republiky

Czech Centre for Phenogenomics

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01140

Reference57 articles.

1. Androstane metabolites bind to and deactivate the nuclear receptor CAR-β

2. Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands

3. The Roles of Xenobiotic Receptors: Beyond Chemical Disposition

4. Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease

5. The Constitutive Androstane Receptor Is an Anti-obesity Nuclear Receptor That Improves Insulin Sensitivity

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