Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis-Reference-Cited by-同舟云学术

Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis

Published:2022-08-22 Issue:17 Volume:65 Page:11726-11744
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mohamed Abdelrahman¹²,Salah Mohamed¹³,Tahoun Mariam¹^ORCID,Hawner Manuel¹,Abdelsamie Ahmed S.⁴⁵^ORCID,Frotscher Martin¹^ORCID

Affiliation:

1. Department of Pharmacy, Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C23, Saarbrücken D-66123, Germany

2. Pharmaceutical Organic Chemistry Department, Assiut University, Assiut 71526, Egypt

3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts, Cairo 12451, Egypt

4. Department of Chemistry of Natural and Microbial Products, Institute of Pharmaceutical and Drug Industries Research, National Research Centre, El-Buhouth St., Dokki, P.O. Box 12622 Cairo 12451, Egypt

5. Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Campus Building E81, Saarbrücken 66123, Germany

Funder

Deutscher Akademischer Austauschdienst

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00589

Reference120 articles.

1. Inhibition of Type 1 17β-Hydroxysteroid Dehydrogenase Impairs the Synthesis of 17β-Estradiol in Endometriosis Lesions

2. Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis

3. Dienogest reduces HSD17β1 expression and activity in endometriosis

4. Involvement of up-regulation of 17?-hydroxysteroid dehydrogenase type 1 in maintenance of intratumoral high estradiol levels in postmenopausal breast cancers

5. Molecular therapy of breast cancer: progress and future directions

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1. Potent Dual Inhibitors of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for In Vivo Proof-of-Principle Studies in an Endometriosis Mouse Model;Journal of Medicinal Chemistry;2023-06-27

2. Targeting the formation of estrogens for treatment of hormone dependent diseases–current status;Frontiers in Pharmacology;2023-04-28