Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21-Reference-Cited by-全球学者库

Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21

Published:2023-02-20 Issue:5 Volume:66 Page:3431-3447
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Göricke Fabian¹,Vu Victoria²,Smith Leanna²,Scheib Ulrike³,Böhm Raphael³,Akkilic Namik³,Wohlfahrt Gerd⁴,Weiske Jörg³,Bömer Ulf³,Brzezinka Krzysztof³,Lindner Niels¹,Lienau Philip⁴,Gradl Stefan⁴,Beck Hartmut¹^ORCID,Brown Peter J.²^ORCID,Santhakumar Vijayaratnam²^ORCID,Vedadi Masoud²⁵^ORCID,Barsyte-Lovejoy Dalia²,Arrowsmith Cheryl H.²^ORCID,Schmees Norbert³,Petersen Kirstin⁴

Affiliation:

1. Research & Development, Pharmaceuticals, Bayer AG, 42096 Wuppertal, Germany

2. Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada

3. Nuvisan Innovation Campus Berlin, 13353 Berlin, Germany

4. Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany

5. Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada

Funder

Bayer

Merck KGaA

Genentech

Kungliga Tekniska H?gskolan

Diamond Light Source