Homologation of the Alkyl Side Chain of Antimitotic Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonate Prodrugs Selectively Targeting CYP1A1-Expressing Breast Cancers Improves Their Stability in Rodent Liver Microsomes-Reference-Cited by-同舟云学术

Homologation of the Alkyl Side Chain of Antimitotic Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonate Prodrugs Selectively Targeting CYP1A1-Expressing Breast Cancers Improves Their Stability in Rodent Liver Microsomes

Published:2023-02-13 Issue:4 Volume:66 Page:2477-2497
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chavez Alvarez Atziri Corin¹²³^ORCID,Bouzriba Chahrazed¹²^ORCID,Moreau Emmanuel⁴⁵^ORCID,Auzeloux Philippe⁴⁵,Besse Sophie⁴⁵,Ouellette Vincent¹²^ORCID,Zarifi Khosroshahi Mitra¹²,Côté Marie-France²,Pilote Sylvie³,Miot-Noirault Elisabeth⁴⁵,Chezal Jean-Michel⁴⁵,Simard Chantale¹³,C -Gaudreault René²⁶,Fortin Sébastien¹²^ORCID

Affiliation:

1. Faculté de pharmacie, Université Laval, Québec, Québec G1V 0A6, Canada

2. Axe oncologie, Hôpital Saint-François d’Assise, Centre de recherche du CHU de Québec-Université Laval, 10, Rue de l’Espinay, Québec, Québec G1L 3L5, Canada

3. Axe cardiologie, Centre de Recherche de l’Institut universitaire de cardiologie et pneumologie de Québec-Université Laval, 2725 chemin Sainte-Foy, Québec, Québec G1V 4G5, Canada

4. Imagerie Moléculaire et Stratégies Théranostiques, Université Clermont-Auvergne, BP 184, F-63005 Clermont-Ferrand, France

5. INSERM U1240 IMoST, Université Clermont Auvergne, F-63000 Clermont-Ferrand, France

6. Département de médecine moléculaire, Faculté de médecine, Université Laval, Québec, Québec G1V 0A6, Canada

Funder

Fonds de Recherche du Qu?bec - Sant?

Centre Hospitalier Universitaire de Qu?bec

Merck Sharp and Dohme

Universit? Laval

Canada Foundation for Innovation

R?seau Qu?b?cois de Recherche sur les M?dicaments

Institute of Cancer Research

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01268

Reference36 articles.

1. World Health Organization, GLOBOCAN, The Global Cancer Observatory. Cancer today. https://gco.iarc.fr/today/online-analysis-pie?v=2020&mode=cancer&mode_population=continents&population=900&populations=900&key=total&sex=0&cancer=39&type=0&statistic=5&prevalence=0&population_group=0&ages_group%5B%5D=0&ages_group%5B%5D=17&nb_items=7&group_cancer=1&include_nmsc=1&include_nmsc_other=1&half_pie=0&donut=0, 2020. (accessed 10 June 2022).

2. World Health Organization, GLOBOCAN. Cancer tomorrow. https://gco.iarc.fr/tomorrow/en/dataviz/tables?types=1&sexes=2&mode=cancer&group_populations=1&multiple_populations=1&multiple_cancers=1&cancers=20&populations=124_840, 2020. (accessed 10 June 2022).

3. Current Operative Management of Breast Cancer: An Age of Smaller Resections and Bigger Cures

4. Radiation Therapy in the Management of Breast Cancer

5. Hormone Therapy in Breast Cancer

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