High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT)
Author:
Affiliation:
1. BioKin Ltd., Watertown, Massachusetts 02472, United States
2. Jubilant Biosys Ltd., Yeshwantpur, Bangalore, 560 022 Karnataka, India
3. Sanofi Research and Development, Industriepark Hoechst, H823, D-65926 Frankfurt am Main, Germany
Funder
National Institutes of Health
National Science Foundation
Harvard University
Blavatnik Family Foundation
U.S. Department of Energy
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01238
Reference80 articles.
1. Nicotinamide N -Methyltransferase: More Than a Vitamin B3 Clearance Enzyme
2. Nicotinamide N-Methyltransferase Interacts with Enzymes of the Methionine Cycle and Regulates Methyl Donor Metabolism
3. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization
4. NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink
5. The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition
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