Discovery of 8-Methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one Derivatives as Highly Potent and Selective Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitors-Reference-Cited by-同舟云学术

Discovery of 8-Methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one Derivatives as Highly Potent and Selective Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitors

Published:2020-03-25 Issue:8 Volume:63 Page:3956-3975
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li Zizhou¹²,Xiao Senhao²³⁴,Yang Yaxi¹²,Chen Chao¹²,Lu Tian²³,Chen Zhifeng³,Jiang Hualiang³,Chen Shijie³,Luo Cheng²³^ORCID,Zhou Bing¹²^ORCID

Affiliation:

1. Department of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China

2. University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China

3. Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China

4. School of Life Science and Technology, Shanghai Tech University, Shanghai 200031, China

Funder

Ministry of Science and Technology of the People's Republic of China

K. C. Wong Education Foundation

Youth Innovation Promotion Association of the Chinese Academy of Sciences

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Chinese Communist Party Central Committee

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine