Design, Synthesis, and Structure–Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors

Author:

Yang Jianzhang1,Shibu Marthandam Asokan2,Kong Lulu3,Luo Jinfeng4,BadrealamKhan Farheen2,Huang Yanhui4,Tu Zheng-Chao4,Yun Cai-Hong3ORCID,Huang Chih-Yang256,Ding Ke1ORCID,Lu Xiaoyun1ORCID

Affiliation:

1. International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China

2. Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan

3. Department of Biochemistry and Biophysics, Institute of Systems Biomedicine and Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China

4. Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China

5. Department of Health and Nutrition Biotechnology, Asia University, Taichung 41354, Taiwan

6. College of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien 970, Taiwan

Funder

National Natural Science Foundation of China

Guangdong Provincial Science and Technology Project

Guangdong Natural Science Funds

Guangzhou City Key Laboratory of Precision Chemical Drug Development

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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