Structural Modification, In Vitro, In Vivo, Ex Vivo, and In Silico Exploration of Pyrimidine and Pyrrolidine Cores for Targeting Enzymes Associated with Neuroinflammation and Cholinergic Deficit in Alzheimer’s Disease-Reference-Cited by-同舟云学术

Structural Modification, In Vitro, In Vivo, Ex Vivo, and In Silico Exploration of Pyrimidine and Pyrrolidine Cores for Targeting Enzymes Associated with Neuroinflammation and Cholinergic Deficit in Alzheimer’s Disease

Published:2021-10-13 Issue:21 Volume:12 Page:4123-4143
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Javed Muhammad Aamir¹,Ashraf Nighat¹,Saeed Jan Muhammad²,Mahnashi Mater H.³,Alqahtani Yahya S.³,Alyami Bandar A.³,Alqarni Ali O.³,Asiri Yahya I.⁴,Ikram Muhammad⁵,Sadiq Abdul⁶,Rashid Umer¹^ORCID

Affiliation:

1. Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, 22060 Abbottabad, Pakistan

2. Department of Pharmacy, University of Swabi, 23430 Swabi, KP, Pakistan

3. Department of Pharmaceutical Chemistry, College of Pharmacy, Najran University, 1988 Najran, Saudi Arabia

4. Department of Pharmacology and Toxicology, College of Pharmacy, King Khalid University, 1882 Abha, Saudi Arabia

5. Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, 22060 Abbottabad, KP, Pakistan

6. Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, 18000 Chakdara, Dir (L), KP, Pakistan

Funder

Ministry of Education

Higher Education Commission, Pakistan

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.1c00507

Reference57 articles.

1. Challenges in Designing Therapeutic Agents for Treating Alzheimer’s Disease-from Serendipity to Rationality

2. Current and novel therapeutic molecules and targets in Alzheimer's disease

3. Alzheimer's disease: Targeting the Cholinergic System

4. The history of the cholinergic hypothesis

5. The cholinergic system in aging and neuronal degeneration

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