High Throughput Screening Cascade To Identify Human Aspartate N-Acetyltransferase (ANAT) Inhibitors for Canavan Disease-Reference-Cited by-同舟云学术

High Throughput Screening Cascade To Identify Human Aspartate N-Acetyltransferase (ANAT) Inhibitors for Canavan Disease

Published:2021-09-03 Issue:18 Volume:12 Page:3445-3455
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Nešuta Ondřej¹,Thomas Ajit G.¹,Alt Jesse¹,Hin Niyada¹,Neužilová Anna¹,Long Shunyou²,Tsukamoto Takashi¹³^ORCID,Rojas Camilo¹,Wei Huijun¹³^ORCID,Slusher Barbara S.¹³^ORCID

Affiliation:

1. Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, 855 N. Wolfe Street, Baltimore, Maryland 21205, United States

2. ChemBioCORE, High Throughput Screening Facility, Johns Hopkins University, 733 N. Broadway, Baltimore, Maryland 21205, United States

3. Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21205, United States

Funder

National Institute of Neurological Disorders and Stroke

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.1c00455

Reference31 articles.

1. Canavan disease: A white matter disorder

2. Canavan disease, a rare early-onset human spongiform leukodystrophy: Insights into its genesis and possible clinical interventions

3. Spongy Degeneration of the Neuraxis (Canavan-Van Bogaert Disease) and N-Acetylaspartic Aciduria

4. Aspartoacylase deficiency and N-acetylaspartic aciduria in patients with canavan disease

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3. Cellular and molecular mechanisms of aspartoacylase and its role in Canavan disease;Cell & Bioscience;2024-04-06

4. NAAG synthetase deficiency has only low influence on pathogenesis in a Canavan disease mouse model;Journal of Inherited Metabolic Disease;2023-11-27

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